The successful combination of high-end phage display technology with precise gene libraries allows the efficient generation and rapid screening of peptide libraries with extraordinary complexity. Avoiding the typical problems of standard phage display EPITOPIC can accurately characterize the antibodies’ binding properties by epitope fingerprinting with high precision at the level of single amino acid resolution. Beyond the precise identification of the binding site the accepted modifications for antibody binding are identified. This is essential information for validation and application of antibodies, both for research reagents in clinical applications as well as for therapeutic antibodies and their biosimilars with respect to QC and patentability. The exact knowledge of antibody epitopes is important for understanding (auto-)immune diseases, anti-drug antibodies, infectious diseases or for the development of vaccines as well as.
EPITOPIC’s technologies and services help to speed up research and enable substantially new ways in product development. The insights gained with our technologies are adding significant value to many different products.
- Rapid & reliable epitope identification
- Identify important amino acids
- Position your antibody product against the competitor’s
Header – highlighted epitope sequence D(e/d)xPRAVF of anti-actin-antibody (BD Transduction Laboratories, Nr. 612656) in actin structure